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Plasma Protein Prof...
Plasma Protein Profile of Carotid Artery Atherosclerosis and Atherosclerotic Outcomes : Meta-Analyses and Mendelian Randomization Analyses
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- Lind, Lars (author)
- Uppsala University,Uppsala universitet,Klinisk epidemiologi,Uppsala Univ, Sweden
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- Gigante, Bruna (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Med, Unit Cardiovasc Med, Stockholm, Sweden.
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- Borné, Yan (author)
- Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmö, Lund, Sweden.
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- Rudholm Feldreich, Tobias (author)
- Högskolan Dalarna,Dalarna University College,Dalarna Univ, Sch Hlth & Social Sci, Falun, Sweden.,Medicinsk vetenskap
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- Leppert, Jerzy (author)
- Uppsala University,Uppsala universitet,Centrum för klinisk forskning, Västerås,Uppsala Univ, Sweden
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- Hedberg, Pär (author)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Vastmanland Cty Hosp, Dept Clin Physiol, Västerås, Sweden.,Västmanland Hospital,Uppsala Univ, Sweden; Vastmanland Cty Hosp, Sweden
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- Östgren, Carl Johan (author)
- Linköpings universitet,Linköping University,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Vårdcentralen Ekholmen,Department of Medicine, Boston University, MA, USA,Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.
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- Nyström, Fredrik H (author)
- Linköpings universitet,Linköping University,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Vårdcentralen Cityhälsan Centrum,Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.
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- Sundström, Johan, Professor, 1971- (author)
- Uppsala universitet,Klinisk epidemiologi,Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia.,University of New South Wales,Uppsala Univ, Sweden; Univ New South Wales, Australia
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- Ärnlöv, Johan, 1970- (author)
- Högskolan Dalarna,Karolinska Institutet,Dalarna University College,Dalarna Univ, Sch Hlth & Social Sci, Falun, Sweden.,Medicinsk vetenskap
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- Baldassarre, Damiano (author)
- Univ Milan, Dept Med Biotechnol & Translat Med, Damiano Baldassarre, Milan, Italy.;IRCCS, Ctr Cardiol Monzino, Milan, Italy.,University of Milan
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- Tremoli, Elena (author)
- IRCCS, Ctr Cardiol Monzino, Milan, Italy.
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- Veglia, Fabrizio (author)
- IRCCS, Ctr Cardiol Monzino, Milan, Italy.
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- Hamsten, Anders (author)
- Karolinska Institutet,Karolinska Inst, Dept Med, Unit Cardiovasc Med, Stockholm, Sweden.;Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden.
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- O'Donnell, Christopher J. (author)
- Boston Univ, Dept Med, Boston, MA USA.,Boston University
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- Franceschini, Nora (author)
- Univ North Caroline, Dept Epidemiol, Capel Hill, NC USA.,University of North Carolina
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmö, Lund, Sweden.
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- Nilsson, Jan (author)
- Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lever-, pankreas- och gallvägskirurgi,Forskargrupper vid Lunds universitet,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Hepato-Pancreato-Biliary Surgery,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmö, Lund, Sweden.
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmö, Lund, Sweden.
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- Engström, Gunnar (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmö, Lund, Sweden.
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- Mälarstig, Anders (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Med, Unit Cardiovasc Med, Stockholm, Sweden.
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2021
- 2021
- English.
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In: Arteriosclerosis, Thrombosis and Vascular Biology. - : Lippincott Williams & Wilkins. - 1079-5642 .- 1524-4636. ; 41:5, s. 1777-1788
- Related links:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- OBJECTIVE: To identify causal pathophysiological mechanisms for atherosclerosis and incident cardiovascular events using protein measurements.APPROACH AND RESULTS: Carotid artery atherosclerosis was assessed by ultrasound, and 86 cardiovascular-related proteins were measured using the Olink CVD-I panel in 7 Swedish prospective studies (11 754 individuals). The proteins were analyzed in relation to intima-media thickness in the common carotid artery (IMT-CCA), plaque occurrence, and incident cardiovascular events (composite end point of myocardial infarction or ischemic stroke) using a discovery/replication approach in different studies. After adjustments for traditional cardiovascular risk factors, 11 proteins remained significantly associated with IMT-CCA in the replication stage, whereas 9 proteins were replicated for plaque occurrence and 17 proteins for incident cardiovascular events. NT-proBNP (N-terminal pro-B-type natriuretic peptide) and MMP (matrix metalloproteinase)-12 were associated with both IMT-CCA and incident events, but the overlap was considerably larger between plaque occurrence and incident events, including MMP-12, TIM-1 (T-cell immunoglobulin and mucin domain 1), GDF (growth/differentiation factor)-15, IL (interleukin)-6, U-PAR (urokinase plasminogen activator surface receptor), LOX-1 (lectin-like oxidized LDL [low-density lipoprotein] receptor 1), and TRAIL-R2 (TNF [tumor necrosis factor]-related apoptosis-inducing ligand receptor 2). Only MMP-12 was associated with IMT-CCA, plaque, and incident events with a positive and concordant direction of effect. However, a 2-sample Mendelian randomization analysis suggested that increased MMP-12 may be protective against ischemic stroke (P=5.5x10(-7)), which is in the opposite direction of the observational analyses.CONCLUSIONS: The present meta-analysis discovered several proteins related to carotid atherosclerosis that partly differed in their association with IMT-CCA, plaque, and incident atherosclerotic disease. Mendelian randomization analysis for the top finding, MMP-12, suggests that the increased levels of MMP-12 could be a consequence of atherosclerotic burden rather than the opposite chain of events.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- atherosclerosis
- carotid arteries
- epidemiology
- ischemic stroke
- myocardial infarction
- protein
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Lind, Lars
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Gigante, Bruna
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Borné, Yan
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Rudholm Feldreic ...
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Leppert, Jerzy
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Hedberg, Pär
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Östgren, Carl Jo ...
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Nyström, Fredrik ...
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Sundström, Johan ...
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Ärnlöv, Johan, 1 ...
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Baldassarre, Dam ...
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Tremoli, Elena
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Veglia, Fabrizio
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Hamsten, Anders
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O'Donnell, Chris ...
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Franceschini, No ...
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Orho-Melander, M ...
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Nilsson, Jan
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Melander, Olle
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Engström, Gunnar
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Mälarstig, Ander ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Arteriosclerosis ...
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet
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Linköping University
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Högskolan Dalarna